Overview of Polyethylene Glycol as a Pharmaceutical Excipient

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Characteristics and Properties of MCT Oil<\/h2>Medium-chain triglycerides (MCT oil) are a mixture of triglycerides produced by the esterification reaction between glycerol and the fatty acids Caprylic acid and Capric acid derived from coconut oil or palm oil, with the following properties:<\/p><ul><li>Oil form, colorless or pale yellow, odorless, and tasteless<\/li><li>HLB value: 1<\/li><li>Solidification temperature: 0°C<\/li><li>Insoluble in water, readily soluble in methanol, and miscible with methylene chloride, soybean oil, and other petroleum ethers<\/li><\/ul><h2>2. Applications of MCT Oil in Pharmaceutical Manufacturing <img src=\"\/datafiles\/88336\/upload\/images\/2026-11\/6539db45-1e9f-4511-9298-74058dc5bed0.png\" alt=\"Applications of MCT Oil in Pharmaceutical Manufacturing\"><\/h2><h3>a. MCT Oil as an Energy Source<\/h3><ul><li>Function: Provides energy to the body<\/li><li>Used in injectable and infusion products<\/li><li>Suitable for health supplement products providing energy and nutrition<\/li><\/ul><h3>b. Applications of MCT Oil in Oral Pharmaceuticals<\/h3>Oral pharmaceuticals:<\/strong><\/p><ul><li>Tablets<\/strong><\/span>:<\/strong> Lubricant and anti-sticking agent for punches and dies<\/li><li>Hard capsules and sugar-coated tablets<\/strong><\/span>:<\/strong> Agent that helps increase the intestinal absorption of active ingredients<\/li><li>Softgel capsules<\/strong><\/span>:<\/strong> Oil carrier for the fill formulation, providing energy and improving the solubility of poorly soluble active ingredients<\/li><li>Liquid formulations<\/strong><\/span>:<\/strong> MCT oil is used in emulsions, microemulsions, self-emulsifying systems, solutions, and suspensions containing active ingredients that are unstable or poorly soluble in water, such as Calciferol<\/li><li>Parenteral pharmaceuticals<\/strong><\/span>:<\/strong> Solubilizing agent for lipophilic drug substances in oil-based injectable solutions, emulsions, and injectable suspensions, helping improve the solubility and absorption of active ingredients<\/li><li>Topical pharmaceuticals<\/strong><\/span>:<\/strong> Oil-based vehicle for topical preparations, improving the solubility and bioavailability of lipophilic active ingredients<\/li><li>Suppositories<\/strong><\/span>:<\/strong> Base for suppositories<\/li><li>Used as an alternative antimicrobial agent in pharmaceutical formulations<\/li><\/ul><h2>3. Advantages of MCT Oil in Pharmaceutical Formulations<\/h2><ul><li>Acts as a solvent for lipophilic active ingredients<\/strong><\/span> in pharmaceutical formulations, helping improve solubility and increase the bioavailability of active ingredients<\/li><li>Stable against oxidative agents<\/strong> <\/span>such as light and atmospheric oxygen<\/li><li>Chemically inert<\/strong><\/span>, with no incompatibility with other active ingredients and excipients<\/li><li>Contains no antioxidants, residual solvents, or catalysts<\/li><li>High active ingredient loading capacity<\/li><li>Due to its shorter chain length, it is rapidly metabolized and absorbed<\/strong><\/span> in the digestive system, helping increase the bioavailability of active ingredients<\/li><li>For softgel capsules<\/strong><\/span>:<\/strong> The use of MCT oil in the fill formulation helps reduce the risk of cross-linking in the capsule shell<\/strong><\/span>, which can cause shell hardening, leakage, and difficulties in shell disintegration<\/li><li>For topical preparations<\/strong><\/span>:<\/strong> The use of MCT oil helps improve the spreadability<\/strong><\/span> of the formulation on the skin without affecting the skin's respiratory function, facilitating effective delivery of active ingredients through the skin without causing dryness<\/strong><\/span><\/li><li>The product has high purity<\/strong><\/span> and is manufactured through a strictly controlled process, thereby ensuring good and consistent product quality<\/li><\/ul><h2>4. Mechanism of MCT Oil in Reducing Cross-Linking in Softgel Capsules<\/h2><figure class=\"image\"><img src=\"\/datafiles\/88336\/upload\/images\/2026-11\/SEO WEB IMAGE (1920 x 1080 px) (12).png\" alt=\"Mechanism of MCT Oil in Reducing Cross-Linking in Softgel Capsules\"><\/figure>The mechanism by which MCT helps reduce cross-linking in softgel capsules does not involve inhibiting the reaction between amino groups and carbonyl groups, which is the primary reaction responsible for cross-linking. Instead, it is attributed to the chemical inertness and purity<\/strong> of this material compared with other oils having the same HLB value of 1. Some properties of MCT that help reduce cross-linking in softgel capsules are as follows:<\/p><h3>a. Extremely Low Aldehyde and Peroxide Levels<\/strong><\/h3>Poorly refined vegetable oils often contain unsaturated fatty acids. Over time, these double bonds undergo oxidation to form hydroperoxides, which subsequently decompose into Aldehydes<\/strong>. These Aldehydes are the primary factors that interact with the gelatin capsule shell to form cross-links, resulting in cross-linking.<\/p>In contrast, MCT, typically consisting of C8 and C10 fatty acids, is composed of fully saturated fatty acids with no double bonds, making it highly resistant to oxidation. When MCT is used as a solvent for dissolving lipophilic active ingredients, the concentration of generated Aldehydes is nearly zero.<\/p><h3>b. Moisture Content and Polarity<\/strong><\/h3>Cross-linking requires an aqueous environment to facilitate ionization reactions. MCT has low polarity and a lower moisture-absorbing capacity compared with polar solvents such as PEG 400:<\/p>When PEG 400<\/strong> is used as a solvent, it tends to draw water from the capsule shell into the excipient or absorb moisture from the environment, increasing the rate of hydrolysis and cross-link formation, thereby increasing the risk of cross-linking.<\/p>MCT<\/strong> creates a hydrophobic barrier that maintains the physical and mechanical stability of the capsule shell and limits water migration from the shell, thereby reducing the risk of cross-linking.<\/p><h3>c. Compatibility<\/h3>MCT does not dissolve the gelatin capsule shell and does not penetrate the capsule shell structure as strongly as surfactants or strong organic solvents. This helps maintain the balance of the gelatin network and plasticizer:<\/p><ul><li>When PEG 400<\/strong> is used: PEG has a strong affinity for water and glycerin. It tends to draw glycerin from the capsule shell into the fill. As a result, the shell loses its plasticizer, becoming brittle and more prone to cracking.<\/li><li>When MCT<\/strong> is used: Glycerin is completely insoluble in MCT. Therefore, glycerin remains within the gelatin network of the capsule shell, allowing the shell to retain its flexibility and elasticity.<\/li><\/ul>","image_url":"https:\/\/www.biorichgroup.com\/datafiles\/88336\/upload\/images\/Avatar%20s%E1%BA%A3n%20ph%E1%BA%A9m\/KHUNG%20%2818%29.png","image_thumb_url":"https:\/\/www.biorichgroup.com\/datafiles\/88336\/upload\/thumb_images\/Avatar%20s%E1%BA%A3n%20ph%E1%BA%A9m\/KHUNG%20%2818%29.png","tags":["MCT Oil reduces crosslinking","MCT Oil in softgel capsule manufacturing","MCT Oil as a pharmaceutical excipient","MCT Oil in softgel capsules","MCT Oil for poorly watersoluble active ingredients","MCT Oil in pharmaceuticals"],"count_view":22,"seo_name":"mct-oil-in-pharmaceuticals-and-its-applications-as-an-excipient","date_update":1793794440,"date_created_format":1793709762,"meta_title":"MCT Oil in Pharmaceutical Excipient Applications","meta_desc":"Explore MCT Oil in pharmaceuticals as an oil carrier for poorly water-soluble active ingredients and its application in reducing cross-linking in softgel capsules.","meta_keyword":"MCT Oil reduces crosslinking,MCT Oil in softgel capsule manufacturing,MCT Oil as a pharmaceutical excipient,MCT Oil in softgel capsules,MCT Oil for poorly watersoluble active ingredients,MCT Oil in pharmaceuticals","qr_code":"https:\/\/www.biorichgroup.com\/mct-oil-in-pharmaceuticals-and-its-applications-as-an-excipient"},{"id":759338,"name":"Ginkgo Biloba Extract in Pharmaceuticals and Health Supplements","desc":"Learn about Ginkgo Biloba Extract standardized to 24% flavonoids and 6% terpene lactones, its active components, key characteristics, and applications in supporting cerebral circulation and memory.<\/p>","content":"<h2><img src=\"\/datafiles\/88336\/upload\/images\/2026-11\/SEO WEB IMAGE (1920 x 1080 px) (10).png\" alt=\"Active Components of Ginkgo Biloba Extract\"> 1. Active Components of Ginkgo Biloba Extract<\/strong><\/h2><ul><li>Ginkgo Biloba Extract is derived from the leaves of Ginkgo biloba<\/i> (the Ginkgo tree), one of the oldest plant species in the world, and has been widely used in both modern and traditional medicine.<\/li><li>In the pharmaceutical and dietary supplement industries, Ginkgo Biloba Extract is considered a strategic ingredient in products designed to support cerebral circulation, enhance memory, and provide neuroprotective antioxidant effects.<\/li><li>Thanks to modern extraction technologies, Ginkgo Biloba Extract is commonly standardized to 24% flavone glycosides and 6% terpene lactones, helping ensure consistent biological activity and compliance with international pharmaceutical standards.<\/li><li>For pharmaceutical and health supplement manufacturers, Ginkgo Biloba Extract is not merely a traditional herbal ingredient but also a scientifically valuable active ingredient in formulations targeting brain and nervous system health.<\/li><\/ul><h2>2. Role of Terpene Lactones in Ginkgo Biloba Extract<\/strong> <img src=\"\/datafiles\/88336\/upload\/images\/2026-11\/be17658f-3228-4677-82af-899b34f4c977.png\" alt=\"Role of Terpene Lactones in Ginkgo Biloba Extract\"><\/h2>The biological effects of Ginkgo Biloba Extract are primarily attributed to its bioactive compounds.<\/strong><\/p>The main components include:<\/strong><\/p><ul><li>Flavonoid Glycosides (≥ 24%)<\/strong><\/span>: This group of compounds possesses strong antioxidant properties, helping protect neuronal cells from damage caused by free radicals.<\/li><li>Terpene Lactones (≥ 6%)<\/strong><\/span>: These include Ginkgolides and Bilobalide, which play roles in enhancing cerebral blood circulation and improving neurological function.<\/li><li>Ginkgolide<\/strong><\/span>: Inhibits platelet-activating factor (PAF), helping improve blood circulation.<\/li><li>Bilobalide<\/strong><\/span>: Supports neuronal protection and enhances cognitive function.<\/li><\/ul>Through the combination of these active compounds, Ginkgo Biloba Extract has become one of the most extensively studied herbal extracts in the field of brain health.<\/p><h2>3. Key Characteristics of Ginkgo Biloba Extract<\/strong><\/h2>Ginkgo Biloba Extract is considered a premium ingredient in products targeting brain and nervous system health due to its numerous outstanding advantages:<\/strong><\/p><ul><li>Standardized Active Compounds According to International Standards<\/strong><\/span>: Standardized flavonoid and terpene lactone contents help ensure consistent biological activity.<\/li><li>Extensively Studied in Clinical Research<\/strong><\/span>: Numerous clinical studies have demonstrated the efficacy of Ginkgo Biloba in improving memory and cerebral circulation.<\/li><li>Strong Market Trend<\/strong><\/span>: Products targeting memory enhancement, brain health support, and neuroaging prevention are experiencing strong growth in the global market.<\/li><\/ul><h2>4. Applications of Ginkgo Biloba Extract in Brain Health<\/strong> <img src=\"\/datafiles\/88336\/upload\/images\/2026-11\/52b6ba7b-7405-40d3-a8e9-35e029328bbf.png\" alt=\"Applications of Ginkgo Biloba Extract in Brain Health\"><\/strong><\/span><\/h2>Ginkgo Biloba Extract provides several important biological benefits for the nervous system and cerebral circulation:<\/strong><\/p><ul><li>Improvement of Blood Circulation<\/strong><\/span>: Enhances blood flow to the brain and peripheral organs through two mechanisms: inhibition of platelet-activating factor and regulation of vascular tone and elasticity, thereby promoting more efficient blood circulation.<\/li><li>Antioxidant Properties<\/strong><\/span>: Exhibits antioxidant activity in the brain, retina, and cardiovascular system. In particular, in the brain, the active compounds help reduce free radical-induced damage and protect neuronal cells against oxidative stress.<\/li><li>Support for Slowing the Manifestations of Aging<\/strong><\/span>: May benefit various symptoms commonly observed in older adults, such as anxiety, depression, memory impairment, reduced cognitive ability, dizziness, headaches, and other related manifestations.<\/li><li>Enhancement of Memory and Cognitive Function<\/strong><\/span>: Has been reported to be effective in improving memory, concentration, and cognitive functions.<\/li><\/ul>Ginkgo Biloba Extract is supplied in powder form and is suitable for various dosage forms, including tablets, hard capsules, oral suspensions, and powders or granules for suspension preparation.<\/p>","image_url":"https:\/\/www.biorichgroup.com\/datafiles\/88336\/upload\/images\/Avatar%20s%E1%BA%A3n%20ph%E1%BA%A9m\/KHUNG%20%2817%29.png","image_thumb_url":"https:\/\/www.biorichgroup.com\/datafiles\/88336\/upload\/thumb_images\/Avatar%20s%E1%BA%A3n%20ph%E1%BA%A9m\/KHUNG%20%2817%29.png","tags":["Flavonoid Glycosides","Terpene Lactones","Ginkgo Biloba Extract","Ginkgo Biloba Extract 24 6","FlavonoidRich Ginkgo Biloba Extract"],"count_view":23,"seo_name":"ginkgo-biloba-extract-in-pharmaceuticals-and-health-supplements","date_update":1793685780,"date_created_format":1793687100,"meta_title":"Ginkgo Biloba Extract in Brain Health","meta_desc":"Learn about Ginkgo Biloba Extract standardized to 24% flavonoids and 6% terpene lactones, its active components, key characteristics, and applications in supporting cerebral circulation and memory.","meta_keyword":"Flavonoid Glycosides,Terpene Lactones,Ginkgo Biloba Extract,Ginkgo Biloba Extract 24 6,FlavonoidRich Ginkgo Biloba Extract","qr_code":"https:\/\/www.biorichgroup.com\/ginkgo-biloba-extract-in-pharmaceuticals-and-health-supplements"},{"id":759337,"name":"Taste-Masking Film Coating Techniques and Polymer Applications","desc":"Explore taste-masking film coating in pharmaceutical formulation, its mechanisms, advantages, disadvantages, and common polymers such as methacrylate copolymers.<\/p>","content":"<h2><img src=\"\/datafiles\/88336\/upload\/images\/2026-11\/SEO WEB IMAGE (1920 x 1080 px) (9).png\" alt=\"The Role of Taste-Masking Film Coating in Pharmaceutical Formulation\"> 1. The Role of Taste-Masking Film Coating in Pharmaceutical Formulation<\/strong><\/h2><ul><li>Among the various methods used to mask the bitter taste of active pharmaceutical ingredients (APIs), taste-masking film coating is a widely used technique to improve the acceptability of oral medications, enhance patient compliance, and support therapeutic effectiveness. It is particularly suitable for medications intended for pediatric and elderly patients, as well as rapidly dissolving dosage forms.<\/li><li>Film coating creates a physical barrier that prevents the API from coming into direct contact with saliva for a short period while the drug remains in the oral cavity, thereby reducing or eliminating the perception of bitterness.<\/li><li>The principle of taste-masking film coating is based on two main mechanisms:<\/li><li>Formation of a diffusion barrier<\/strong><\/span>:<\/strong> This is the most common mechanism. The film coating is insoluble or dissolves very slowly in saliva, preventing the API from diffusing out during the first 30–60 seconds in the oral cavity. The API then begins to be released when the dosage form reaches the stomach.<\/li><li>Control of dissolution rate<\/strong><\/span>:<\/strong> The film coating is designed with an appropriate dissolution rate, allowing it to dissolve slowly at salivary pH (~6.8) and more rapidly in gastric fluid (pH ~1.2). As a result, the API does not reach a sufficient concentration in the oral cavity to trigger the perception of bitterness.<\/li><\/ul><h2>2. Advantages and Disadvantages of Taste-Masking Film Coating Compared with Other Bitter Taste-Masking Methods<\/strong> <img src=\"\/datafiles\/88336\/upload\/images\/2026-11\/23f712aa-c8c9-4e9c-a978-c001e626b9d1.png\" alt=\"Advantages and Disadvantages of Taste-Masking Film Coating Compared with Other Bitter Taste-Masking Methods\"><\/strong><\/h2>Advantages:<\/strong><\/p><ul><li>Easy to implement using conventional equipment and machinery available in pharmaceutical manufacturing facilities.<\/li><li>Does not require investment in new equipment or technologies.<\/li><li>Does not alter the chemical nature of the API, thereby reducing the risk of changes in chemical stability and minimizing potential incompatibilities.<\/li><li>Highly effective for many bitter APIs, including clarithromycin, cetirizine, dextromethorphan, and diphenhydramine.<\/li><li>The film coating also helps protect the tablet core from environmental factors such as oxygen, moisture, and light, while improving the tablet's appearance.<\/li><li>Does not significantly increase tablet size, as the film coating accounts for only approximately 3–5% of the tablet weight.<\/li><li>Allows flexible adjustment of the coating formulation, including polymer type, film thickness, and film permeability.<\/li><\/ul>Disadvantages:<\/strong><\/p><ul><li>Less effective for highly insoluble and intensely bitter APIs, such as quinine and levocetirizine.<\/li><li>May delay API dissolution.<\/li><li>Not suitable for chewable tablets, orally disintegrating tablets (ODTs), or powders and sachets intended for suspension preparation.<\/li><li>The effectiveness of the film-coating process depends significantly on the experience and technical expertise of the formulator.<\/li><li>Risk of film cracking or breakage, which may result in bitterness being perceived by patients.<\/li><\/ul><h2>3. Polymers Commonly Used in Taste-Masking Film Coating<\/strong> <img src=\"\/datafiles\/88336\/upload\/images\/2026-11\/tải xuống (1).png\" alt=\"Polymers Commonly Used in Taste-Masking Film Coating\"><\/strong><\/h2>Polymers commonly used in taste-masking film coating include water-insoluble or poorly water-soluble polymers such as ethyl cellulose, methacrylate copolymers, cellulose acetate, and shellac. In addition, water-soluble polymers such as HPMC and PVA can also be used.<\/p><ul><li>Among these, methacrylate copolymers are one of the most widely used polymers for this application, offering the following advantages:<\/li><li>Good solubility in ethanol, isopropyl alcohol, and acetone, while being insoluble in water.<\/li><li>Dissolves well at pH &lt; 5.0; insoluble at oral pH ???? provides good masking effect while ensuring active ingredient release in the stomach.<\/li><li>Dissolves readily in the stomach, reducing the risk of delaying API dissolution.<\/li><li>Forms films with good mechanical properties, providing tablets with an attractive glossy appearance, improved swallowability, and strong adhesion between the coating layer and the tablet core.<\/li><li>High masking ability requires only a low coating weight gain ???? saving time, materials, and costs.<\/li><li>Low viscosity, facilitating coating solution preparation and the film-coating process while reducing the risk of spray nozzle clogging.<\/li><li>Compatible with a wide range of APIs and excipients.<\/li><li>Regulated in USP\/NF and Ph.Eur monographs ???? convenient for product registration.<\/li><\/ul>","image_url":"https:\/\/www.biorichgroup.com\/datafiles\/88336\/upload\/images\/Avatar%20s%E1%BA%A3n%20ph%E1%BA%A9m\/KHUNG%284%29.png","image_thumb_url":"https:\/\/www.biorichgroup.com\/datafiles\/88336\/upload\/thumb_images\/Avatar%20s%E1%BA%A3n%20ph%E1%BA%A9m\/KHUNG%284%29.png","tags":["tastemasking film coating","tastemasking film coating technique","bitter tastemasking film coating","tastemasking film coating polymer","ethyl cellulose","cellulose acetate"],"count_view":27,"seo_name":"taste-masking-film-coating-techniques-and-polymer-applications","date_update":1793669760,"date_created_format":1793683850,"meta_title":"Taste-Masking Film Coating in Pharmaceutical Formulation","meta_desc":"Explore taste-masking film coating in pharmaceutical formulation, its mechanisms, advantages, disadvantages, and common polymers such as methacrylate copolymers.","meta_keyword":"tastemasking film coating,tastemasking film coating technique,bitter tastemasking film coating,tastemasking film coating polymer,ethyl cellulose,cellulose acetate","qr_code":"https:\/\/www.biorichgroup.com\/taste-masking-film-coating-techniques-and-polymer-applications"},{"id":758944,"name":"HP-β-CD: An Excipient for Improving Solubility and Stability in Injectable Formulations","desc":"Learn about HP-β-CD (Hydroxypropyl-β-cyclodextrin), a leading excipient for improving solubility and stability and reducing toxicity risks in injectable formulations.<\/p>","content":"<h2><img src=\"\/datafiles\/88336\/upload\/images\/2026-10\/SEO WEB IMAGE (1920 x 1080 px)(7).png\" alt=\"Hydroxypropyl-β-cyclodextrin\"> 1. Origin and characteristics of Hydroxypropyl-β-cyclodextrin<\/strong><\/h2>Hydroxypropyl-β-cyclodextrin (HP-β-CD) is a semi-synthetic derivative of β-cyclodextrin, produced by introducing hydroxypropyl groups onto the hydroxyl groups of the β-cyclodextrin molecule. This structural modification significantly improves water solubility, reduces renal toxicity, and minimizes crystallization compared with native β-cyclodextrin. <img src=\"\/datafiles\/88336\/upload\/images\/2026-10\/image(13).png\" alt=\"Structure of 2-hydroxypropyl-β-cyclodextrin (on the left) and its... | Download Scientific Diagram\"><\/span><\/p>Structure of 2-hydroxypropyl-β-cyclodextrin (on the left) and its... | Download Scientific Diagram<\/i><\/p>Due to its ability to form inclusion complexes with many poorly water-soluble active pharmaceutical ingredients (APIs), HP-β-CD is one of the most widely used excipients in injectable formulations. It helps improve solubility and chemical stability for hydrophobic APIs without requiring large amounts of organic solvents or surfactants.<\/p>HP-β-CD is currently used in numerous pharmaceutical products accepted by regulatory agencies such as the FDA and EMA, with various commercial products marketed worldwide.<\/p><h2>2. Structure and physicochemical properties of HP-β-CD<\/strong><\/h2>HP-β-CD retains the characteristic truncated cone-shaped structure of cyclodextrins, consisting of:<\/strong><\/p><ul><li>A hydrophobic inner cavity<\/li><li>A hydrophilic outer surface<\/li><li>An average molecular weight of approximately 1,300–1,500 Da, depending on the degree of hydroxypropyl substitution.<\/li><\/ul>The introduction of hydroxypropyl groups provides several advantages:<\/strong><\/p><ul><li>Increases water solubility from approximately 18 mg\/mL for β-CD to over 500–600 mg\/mL.<\/li><li>Reduces the tendency to crystallize.<\/li><li>Reduces interactions with membrane cholesterol.<\/li><li>Lowers the risk of renal toxicity.<\/li><li>Makes it suitable for injectable and intravenous formulations.<\/li><\/ul><h2>3. Mechanism of HP-β-CD inclusion complex formation<\/strong><\/h2>The hydrophobic cavity of HP-β-CD can accommodate part or all of a hydrophobic API molecule through non-covalent interactions.<\/strong><\/p><ul><li>API + HP-β-CD ⇌ API–HP-β-CD complex<\/li><li>Other Cyclodextrin Series – CD Bioparticles<\/i><\/li><li>This process maintains the API in equilibrium between its free and complexed forms. After administration, the complex can dissociate as the API is absorbed or distributed, releasing the active ingredient to exert its therapeutic effect.<\/li><\/ul><h2>4. Why choose HP-β-CD for injectable formulations?<\/strong><\/h2><ul><li>Improved apparent solubility<\/strong><\/span>: For APIs with very low aqueous solubility, HP-β-CD can substantially increase the amount of dissolved drug. This mechanism helps reduce precipitation, increase dissolved API concentrations, maintain solution clarity, and improve bioavailability for injectable products. Solubility enhancement may range from several-fold to hundreds-fold, depending on the API's chemical structure and the complex formation constant.<\/li><li>Protection against degradation and improved injectable stability<\/strong><\/span>: When an API is included within the cyclodextrin cavity, the encapsulated portion may have reduced exposure to oxygen, light, moisture, and metal ions, helping protect and stabilize sensitive APIs in injectable formulations. This may contribute to an extended shelf life.<\/li><li>Reduced irritation at the injection site<\/strong><\/span>: By partially including the API within the HP-β-CD cavity, the amount of free API directly exposed to tissues may be reduced. This can help minimize tissue irritation, injection pain, and the risk of API precipitation at the injection site.<\/li><li>Reduced need for organic solvents<\/strong><\/span>: HP-β-CD can reduce or substantially eliminate the need for solubilizing cosolvents such as ethanol, propylene glycol, polyethylene glycol, and benzyl alcohol, potentially reducing solvent-related pain, irritation, and toxicity.<\/li><li>Improved biocompatibility<\/strong><\/span>: HP-β-CD has lower hemolytic potential and lower renal toxicity than native β-CD. It is generally well tolerated when used at appropriate doses and is included in various approved injectable medicines.<\/li><li>Compatibility with other excipients<\/strong><\/span>: HP-β-CD is compatible with many APIs and excipients, supporting injectable formulation optimization.<\/li><\/ul><h2>5. Current applications of HP-β-CD in pharmaceutical formulations<\/strong><\/h2>HP-β-CD is used in injectable formulations for the following purposes:<\/strong><\/p><ul><li>Improving solubility<\/li><li>Protecting and stabilizing APIs<\/li><li>Reducing irritation and injection pain<\/li><li>Extending product shelf life<\/li><\/ul>Beyond intravenous injections, HP-β-CD is also used in:<\/strong><\/p><ul><li>Intramuscular injections<\/li><li>Subcutaneous injections<\/li><li>Sterile ophthalmic solutions<\/li><li>Lyophilized injectable formulations<\/li><li>Biopharmaceutical formulations requiring API stabilization<\/li><\/ul>Some APIs that may benefit from HP-β-CD include:<\/strong><\/p><figure class=\"table\"><table><thead><tr><th style=\"text-align:center;\">API<\/strong><\/th><th style=\"text-align:center;\">Role of HP-β-CD<\/strong><\/th><\/tr><\/thead><tbody><tr><td style=\"text-align:center;\">Voriconazole<\/td><td style=\"text-align:center;\">Improves solubility and can reduce the need for organic solvents<\/td><\/tr><tr><td style=\"text-align:center;\">Ziprasidone mesylate<\/td><td style=\"text-align:center;\">Improves solubility and stability<\/td><\/tr><tr><td style=\"text-align:center;\">Aripiprazole<\/td><td style=\"text-align:center;\">Supports solubilization in injectable formulations<\/td><\/tr><tr><td style=\"text-align:center;\">Itraconazole<\/td><td style=\"text-align:center;\">Improves solubility and may enhance bioavailability<\/td><\/tr><tr><td style=\"text-align:center;\">Diclofenac<\/td><td style=\"text-align:center;\">Supports solubilization and may help reduce irritation<\/td><\/tr><tr><td style=\"text-align:center;\">Dexamethasone<\/td><td style=\"text-align:center;\">Supports solution stability and improves solubility<\/td><\/tr><tr><td style=\"text-align:center;\">Hydrocortisone<\/td><td style=\"text-align:center;\">Supports the preparation of clear injectable solutions<\/td><\/tr><\/tbody><\/table><\/figure>","image_url":"https:\/\/www.biorichgroup.com\/datafiles\/88336\/upload\/images\/Avatar%20s%E1%BA%A3n%20ph%E1%BA%A9m\/KHUNG%20%2814%29.png","image_thumb_url":"https:\/\/www.biorichgroup.com\/datafiles\/88336\/upload\/thumb_images\/Avatar%20s%E1%BA%A3n%20ph%E1%BA%A9m\/KHUNG%20%2814%29.png","tags":["HPβCD excipient","Hydroxypropylβcyclodextrin","HPβCD in injectable formulations","drug solubility enhancement","drug stability improvement","HPβCD inclusion complex","HPβCD structure","HPβCD applications"],"count_view":63,"seo_name":"hp-cd-an-excipient-for-improving-solubility-and-stability-in-injectable-formulations","date_update":1793262120,"date_created_format":1793264044,"meta_title":"HP-β-CD excipient for injectable formulations","meta_desc":"Learn about HP-β-CD (Hydroxypropyl-β-cyclodextrin), a leading excipient for improving solubility and stability and reducing toxicity risks in injectable formulations.","meta_keyword":"HPβCD excipient,Hydroxypropylβcyclodextrin,HPβCD in injectable formulations,drug solubility enhancement,drug stability improvement,HPβCD inclusion complex,HPβCD structure,HPβCD applications","qr_code":"https:\/\/www.biorichgroup.com\/hp-cd-an-excipient-for-improving-solubility-and-stability-in-injectable-formulations"},{"id":758724,"name":"Beta Cyclodextrin Crucial Role In Herbal Formulation","desc":"Discover the application of Beta Cyclodextrin in improving solubility, increasing bioavailability, and effectively masking the bitter taste of herbal active ingredients.<\/p>","content":"<h2><img src=\"\/datafiles\/88336\/upload\/images\/2026-10\/2.jpg\" alt=\"cyclodextrin\"> 1. Solutions for Masking Bitter Taste and Improving the Solubility of Botanical Ingredients Using Cyclodextrin<\/strong><\/h2>Botanical active ingredients are increasingly used in pharmaceuticals and dietary supplements due to their safety profiles and diverse biological activities. However, many natural compounds, such as flavonoids, terpenoids, alkaloids, polyphenols, and essential oils, face two major challenges:<\/p>Low water solubility, which can reduce absorption and bioavailability.<\/p>Bitter or unpleasant taste, which affects patient acceptability and treatment adherence, particularly among children and older adults.<\/p>In recent years, cyclodextrins, particularly β-cyclodextrin (β-CD), have become widely used excipients for simultaneously improving solubility, enhancing stability, and masking the bitter taste of botanical active ingredients without altering their chemical structures.<\/p><h2>2. What Are Cyclodextrin and β-Cyclodextrin?<\/strong><\/h2>Cyclodextrins (CDs) are cyclic oligosaccharides composed of glucose units linked by α-1,4-glycosidic bonds. Cyclodextrins are produced through the enzymatic action of cyclodextrin glycosyltransferase (CGTase) on starch.<\/p>Types of Cyclodextrins:<\/strong><\/p><ul><li>Natural cyclodextrins<\/strong><\/span>:<\/strong> Composed of 6, 7, or 8 glucose units, known respectively as α-, β-, and γ-cyclodextrin.<\/li><li>Alpha Cyclodextrin - an overview | ScienceDirect Topics<\/li><li>Cyclodextrin derivatives<\/strong><\/span>:<\/strong> Modified with substituent groups such as sulfobutyl, hydroxypropyl, or randomly methylated groups. Examples include SBECD, HP-β-CD, and RM-β-CD.<\/li><\/ul>Among these, β-cyclodextrin is one of the most widely used types due to its:<\/strong><\/p><ul><li>Cavity size suitable for many botanical active ingredients.<\/li><li>Reasonable cost.<\/li><li>Established large-scale manufacturing processes.<\/li><li>High safety profile.<\/li><\/ul><h2>3. Mechanisms of Solubility Enhancement and Bitter Taste Masking by β-Cyclodextrin<\/strong><\/h2>β-Cyclodextrin has a ring-shaped molecular structure with two distinctive features:<\/strong><\/p><ul><li>The outer surface contains numerous hydroxyl groups, making it hydrophilic.<\/li><li>The inner cavity provides a relatively hydrophobic environment.<\/li><li>These structural characteristics enable inclusion complex formation through host–guest interactions. When a molecule with a suitably sized and shaped hydrophobic region encounters β-cyclodextrin, an inclusion complex can form through non-covalent interactions, including Van der Waals forces, hydrophobic interactions, hydrogen bonding, and dipole interactions. <img class=\"image_resized\" style=\"width:100%;\" src=\"\/datafiles\/88336\/upload\/images\/2026-10\/image(11).jpeg\" alt=\"The Art of Cyclodextrin Complex Formation\"><\/span><\/li><li>The Art of Cyclodextrin Complex Formation<\/li><li>This process is reversible and does not alter the chemical structure of the active ingredient. The results include:<\/li><li>Improved solubility<\/strong><\/span>:<\/strong> Through host–guest complex formation, poorly soluble active ingredients can be incorporated into the cavity of β-cyclodextrin. This can improve their apparent hydrophilicity, reduce the energy required for dissolution, and promote better dispersion in aqueous media.<\/li><li>Enhanced bioavailability<\/strong><\/span>:<\/strong> β-Cyclodextrin inclusion complexes can improve the dissolution rate and dispersion of certain active ingredients, increasing their contact with gastrointestinal fluids and potentially improving oral bioavailability.<\/li><li>Bitter taste masking<\/strong><\/span>:<\/strong> Hydrophobic groups associated with bitter taste can be accommodated within the β-cyclodextrin cavity. This may reduce the amount of free active ingredient available to interact with bitter taste receptors, thereby reducing the perception of bitterness.<\/li><li>Reduced or prevented irritation caused by certain active ingredients, potentially minimizing undesirable effects.<\/li><li>Reduced interactions between active ingredients and other active ingredients or excipients.<\/li><li>Protection of active ingredients and formulation stabilization<\/strong><\/span>:<\/strong> Helps limit oxidation, reduce the effects of temperature and light on degradation, and minimize evaporation of volatile active ingredients.<\/li><li>Prevention of recrystallization<\/strong><\/span>:<\/strong> Many natural compounds tend to recrystallize after dissolution. Complex formation with β-cyclodextrin can help inhibit recrystallization and maintain the active ingredient in a dissolved or less crystalline state for longer, depending on the compound and formulation conditions.<\/li><\/ul><h2>4. Applications of β-Cyclodextrin in Botanical Dosage Forms<\/strong><\/h2><figure class=\"image\"><img src=\"\/datafiles\/88336\/upload\/images\/2026-10\/f087cfa0-ae77-4844-ab37-710334ee8fb1.png\" alt=\"Applications of β-Cyclodextrin in Botanical Dosage Forms\"><\/figure>β-Cyclodextrin is used to mask bitter taste and improve the solubility and bioavailability of various botanical compounds, including flavonoids, polyphenols, terpenoids, essential oils, alkaloids, and herbal extracts.<\/p>Methods for Forming Complexes Between β-Cyclodextrin and Active Ingredients:<\/strong><\/p><ul><li>Kneading method<\/strong><\/span>:<\/strong> β-Cyclodextrin is moistened with water or an ethanol–water mixture to form a paste. The active ingredient is then added, and the mixture is kneaded continuously for approximately 30–60 minutes. The resulting material is dried, milled, and sieved to obtain a powdered complex.<\/li><li>Dry grinding method<\/strong><\/span>:<\/strong> A ball mill or high-energy mill is used for several hours to promote complex formation and produce a powder.<\/li><li>Spray-drying method<\/strong><\/span>:<\/strong> A solution containing β-cyclodextrin is combined with a solution of the active ingredient and stirred to promote complex formation. The mixture is then processed using a spray dryer or fluid-bed granulator to obtain a powder.<\/li><li>Freeze-drying method<\/strong><\/span>:<\/strong> The solution containing the formed complex is frozen, followed by sublimation of the ice under reduced pressure.<\/li><li>Ultrasonication method<\/strong><\/span>:<\/strong> Ultrasound waves are used to facilitate mixing and promote complex formation.<\/li><li>The typical molar ratio of β-cyclodextrin to the active ingredient is 1:1. However, some active ingredients may require ratios of 1:2 or 2:1.<\/li><\/ul><h2>5. Advantages of Using β-Cyclodextrin for Botanical Active Ingredients<\/strong><\/h2>Botanical active ingredients often lack ionizable functional groups, making certain conventional taste-masking methods, such as complexation with ion-exchange resins, unsuitable. β-Cyclodextrin complex formation is not determined solely by the chemical structure of the active ingredient; it also depends on molecular size, shape, hydrophobicity, and the ability of the molecule to fit into the cyclodextrin cavity. As a result, β-cyclodextrin can form inclusion complexes with a wide range of botanical compounds, potentially improving solubility and masking unpleasant tastes.<\/p>In addition, β-cyclodextrin offers several advantages:<\/strong><\/p><ul><li>Short complexation time, often within a few hours.<\/li><li>No requirement for organic solvents in certain preparation methods, helping reduce residual solvent concerns and fire hazards.<\/li><li>Does not chemically modify the active ingredient or necessarily alter its biological activity.<\/li><li>Compatible with many active ingredients and excipients.<\/li><li>Suitable for various solid and liquid dosage forms and multiple classes of botanical compounds.<\/li><li>Flexible formulation and manufacturing processes that can be scaled up.<\/li><li>Favorable safety profile when used at appropriate levels and in accordance with applicable regulatory requirements.<\/li><\/ul>","image_url":"https:\/\/www.biorichgroup.com\/datafiles\/88336\/upload\/images\/Avatar%20s%E1%BA%A3n%20ph%E1%BA%A9m\/KHUNG%283%29.png","image_thumb_url":"https:\/\/www.biorichgroup.com\/datafiles\/88336\/upload\/thumb_images\/Avatar%20s%E1%BA%A3n%20ph%E1%BA%A9m\/KHUNG%283%29.png","tags":["beta cyclodextrin","beta cyclodextrin applications","herbal bitter taste masking","active ingredient solubility improvement","beta cyclodextrin excipient","beta cyclodextrin complexation","increase bioavailability","beta cyclodextrin in pharmaceuticals"],"count_view":70,"seo_name":"beta-cyclodextrin-crucial-role-in-herbal-formulation","date_update":1793074500,"date_created_format":1793081699,"meta_title":"Overview Of Beta Cyclodextrin Complexation Mechanism","meta_desc":"Discover the application of Beta Cyclodextrin in improving solubility, increasing bioavailability, and effectively masking the bitter taste of herbal active ingredients.","meta_keyword":"beta cyclodextrin,beta cyclodextrin applications,herbal bitter taste masking,active ingredient solubility improvement,beta cyclodextrin excipient,beta cyclodextrin complexation,increase bioavailability,beta cyclodextrin in pharmaceuticals","qr_code":"https:\/\/www.biorichgroup.com\/beta-cyclodextrin-crucial-role-in-herbal-formulation"},{"id":758698,"name":"Pharmaceutical Ethanol The Most Crucial Solvent Today","desc":"Pure ethanol is an indispensable organic solvent in pharmaceutical manufacturing. Discover the outstanding applications and strict standards of pharmaceutical ethanol.<\/p>","content":"<h2><img src=\"\/datafiles\/88336\/upload\/images\/2026-10\/3.jpg\" alt=\"ethanol\"> 1. General introduction to ethanol as a solvent<\/strong><\/h2>Ethanol (ethyl alcohol, C₂H₅OH) is one of the most widely used organic solvents in the pharmaceutical industry due to its ability to dissolve many active pharmaceutical ingredients (APIs), suitable volatility, high compatibility with various APIs and excipients, and well-established safety profile. In pharmaceutical manufacturing, ethanol serves not only as a solvent but also plays an important role in several processes, including herbal extraction, wet granulation, film-coating solution preparation, equipment disinfection, and the formulation of modern drug delivery systems.<\/p>Depending on the intended application, ethanol is available at various concentrations. Among these, high-purity ethanol at 96–100%<\/strong><\/span> is preferred for pharmaceutical manufacturing due to its low water content, high purity, and ability to meet stringent international pharmacopoeial standards.<\/p><h2>2. Key roles of ethanol as a solvent in pharmaceuticals<\/strong> <img src=\"\/datafiles\/88336\/upload\/images\/2026-10\/abf7c3b0-0c2f-4d4d-a612-27c12ec011da.png\" alt=\"Key roles of ethanol as a solvent in pharmaceuticals\"><\/h2>a. Ethanol as a solvent for active ingredients and excipients<\/strong><\/p><ul><li>Ethanol is an effective solvent for many active ingredients that are poorly soluble or insoluble in water, particularly:<\/li><li>Fat-soluble vitamins.<\/li><li>Steroids.<\/li><li>Essential oils.<\/li><li>Alkaloids.<\/li><li>Flavonoids.<\/li><li>Certain lipophilic active ingredients.<\/li><li>In addition to active ingredients, ethanol is used to dissolve various excipients, such as film-forming polymers, plasticizers, flavoring agents, and preservatives, before incorporating them into formulations.<\/li><\/ul>Some dosage forms that use ethanol include:<\/strong><\/p><ul><li>Oral solutions.<\/li><li>Oral drops.<\/li><li>Nasal sprays and throat sprays.<\/li><li>Topical preparations.<\/li><li>Gels and topical solutions.<\/li><\/ul>b. Ethanol as an effective solvent for extraction processes<\/strong><\/p><ul><li>One of the most important applications of ethanol is the extraction of bioactive compounds from medicinal plants.<\/li><li>Compared with water, ethanol can dissolve a broader range of active compounds, including:<\/li><li>Polyphenols.<\/li><li>Flavonoids.<\/li><li>Curcuminoids.<\/li><li>Alkaloids.<\/li><li>Glycosides.<\/li><li>Coumarins.<\/li><li>Terpenoids.<\/li><li>By adjusting ethanol concentration (e.g., 50%, 70%, 80%, or 96%), manufacturers can optimize extraction yield and improve selectivity for specific target compounds.<\/li><\/ul>c. The role of ethanol in wet granulation for tablet manufacturing<\/strong><\/p><ul><li>In wet granulation, ethanol is commonly used as a solvent to prepare binder solutions, such as:<\/li><li>Povidone (PVP).<\/li><li>Hypromellose (HPMC).<\/li><li>Ethyl cellulose.<\/li><li>Copovidone.<\/li><li>For active ingredients that are sensitive to water, ethanol can help to:<\/li><li>Reduce the risk of hydrolysis.<\/li><li>Shorten drying time.<\/li><li>Promote uniform granule formation.<\/li><li>Improve granule flowability.<\/li><\/ul>d. Solvent for Tablet Film-Coating Solutions<\/strong><\/p><ul><li>Many film-coating formulations use ethanol to dissolve film-forming polymers, such as:<\/li><li>Shellac.<\/li><li>Ethyl cellulose.<\/li><li>Acrylic polymer derivatives.<\/li><li>Taste-masking coating polymers.<\/li><li>Due to its rapid evaporation rate, ethanol helps to:<\/li><li>Shorten film-coating time.<\/li><li>Produce a uniform film layer.<\/li><li>Reduce tablet sticking.<\/li><li>Improve the appearance of finished film-coated tablets.<\/li><li>In particular, ethanol is often used in non-aqueous film-coating systems for active ingredients that are highly sensitive to moisture.<\/li><\/ul>e. Ethanol in the development of modern dosage forms<\/strong><\/p><ul><li>In modern pharmaceutical technologies, ethanol is used in the preparation of:<\/li><li>Nanoparticles.<\/li><li>Liposomes.<\/li><li>Nanoemulsions.<\/li><li>Solid dispersions.<\/li><li>Polymeric micelles.<\/li><li>Self-emulsifying drug delivery systems (SEDDS\/SMEDDS).<\/li><li>Ethanol acts as a solvent for lipids, polymers, or active ingredients before the formation of nanoscale dispersions, potentially improving the solubility and bioavailability of poorly water-soluble active ingredients.<\/li><\/ul>f. Disinfection and safe cleaning of pharmaceutical manufacturing equipment<\/strong><\/p><ul><li>Beyond its role as an excipient, ethanol is widely used for:<\/li><li>Equipment cleaning.<\/li><li>Surface disinfection.<\/li><li>Cleaning production pipelines.<\/li><li>Cleanroom sanitation.<\/li><li>Disinfection of tools and equipment before manufacturing.<\/li><li>Ethanol at approximately 70% is commonly used for disinfection, while ethanol at 96–100% may be used to prepare disinfectant solutions according to the requirements of specific procedures.<\/li><\/ul><h2>3. Why high-purity ethanol at 96–100% is used in pharmaceutical manufacturing ?<\/strong><\/h2>Although ethanol is a widely available raw material, not all grades are suitable for pharmaceutical manufacturing. Pharmaceutical-grade ethanol must meet stringent quality standards to ensure the safety, efficacy, and stability of the finished product.<\/p>a. Limiting harmful impurities<\/strong><\/p><ul><li>Ethanol used in pharmaceuticals must be strictly controlled for impurities such as:<\/li><li>Methanol.<\/li><li>Acetaldehyde.<\/li><li>Fusel oils.<\/li><li>Benzene.<\/li><li>Heavy metals.<\/li><li>Other volatile organic compounds.<\/li><li>Using high-purity ethanol helps reduce the risk of harmful impurities remaining in the finished product, particularly in oral medicines, injectable products, and preparations intended for children.<\/li><\/ul>b. Reducing water content<\/strong><\/p><ul><li>Ethanol at 96–100% contains relatively little water, offering several benefits:<\/li><li>Limits hydrolysis of active ingredients.<\/li><li>Improves chemical stability.<\/li><li>Reduces the risk of microbial growth.<\/li><li>Improves the solubility of lipophilic substances.<\/li><li>Enhances extraction efficiency.<\/li><li>This is particularly important for active ingredients or excipients that are sensitive to moisture.<\/li><\/ul>c. Ensuring reproducibility in manufacturing processes<\/strong><\/p><ul><li>Consistent ethanol purity helps maintain process parameters and ensures greater uniformity between production batches, including:<\/li><li>Solvent capacity.<\/li><li>Evaporation rate.<\/li><li>Viscosity.<\/li><li>Density.<\/li><li>Wet granulation performance.<\/li><li>Film-coating quality.<\/li><\/ul>d. Compliance with international pharmacopoeial standards<\/strong><\/p><ul><li>Ethanol used in pharmaceutical manufacturing generally needs to comply with the requirements of the following pharmacopoeias: USP, Ph. Eur., BP, and JP.<\/li><li>These standards establish strict requirements for:<\/li><li>Identification.<\/li><li>Ethanol content.<\/li><li>Impurity limits.<\/li><li>Methanol limits.<\/li><li>Water content.<\/li><li>Residue on evaporation.<\/li><li>Acidity and alkalinity.<\/li><li>Other physicochemical parameters.<\/li><li>Selecting pharmacopoeial-grade ethanol helps pharmaceutical manufacturers meet GMP requirements and international quality management regulations.<\/li><\/ul><h2>Conclusion<\/strong><\/h2>High-purity ethanol at 96–100% is an essential raw material in pharmaceutical formulation and manufacturing. Its applications range from dissolving active ingredients and extracting medicinal plants to wet granulation, film coating, advanced drug delivery system development, and disinfection in manufacturing facilities. With its low water content, high purity, and ability to meet international pharmacopoeial standards, pharmaceutical-grade ethanol contributes to the quality, stability, and safety of finished products. Therefore, selecting a compliant ethanol supplier is not only a technical requirement but also an important factor in maintaining consistent manufacturing processes and meeting increasingly stringent quality standards.<\/p>Biorich supplies high-purity ethanol grades for pharmaceutical formulation and manufacturing, including:<\/p><ul><li>Ethanol 96%.<\/li><li>Ethanol 100%.<\/li><\/ul>These products are supplied with relevant certifications and registration documentation to support compliance with the stringent requirements of international pharmacopoeial standards.<\/p>","image_url":"https:\/\/www.biorichgroup.com\/datafiles\/88336\/upload\/images\/Avatar%20s%E1%BA%A3n%20ph%E1%BA%A9m\/KHUNG%20%282%29%281%29.png","image_thumb_url":"https:\/\/www.biorichgroup.com\/datafiles\/88336\/upload\/thumb_images\/Avatar%20s%E1%BA%A3n%20ph%E1%BA%A9m\/KHUNG%20%282%29%281%29.png","tags":["pure ethanol","ethanol 96 100","applications of ethanol","herbal extraction solvent","solubilizing solvent","pharmaceutical ethanol","ethanol in pharmaceuticals","ethanol in pharmaceutical manufacturing"],"count_view":62,"seo_name":"pharmaceutical-ethanol-the-most-crucial-solvent-today","date_update":1793229480,"date_created_format":1793072034,"meta_title":"Overview Of Ethanol Solvent In Pharmaceutical Manufacturing","meta_desc":"Pure ethanol is an indispensable organic solvent in pharmaceutical manufacturing. Discover the outstanding applications and strict standards of pharmaceutical ethanol.","meta_keyword":"pure ethanol,ethanol 96 100,applications of ethanol,herbal extraction solvent,solubilizing solvent,pharmaceutical ethanol,ethanol in pharmaceuticals,ethanol in pharmaceutical manufacturing","qr_code":"https:\/\/www.biorichgroup.com\/pharmaceutical-ethanol-the-most-crucial-solvent-today"}]},"widget_17042920":{"content_data":{"content":"Mở\/Đóng"}},"widget_17042921":{"content_data":{"content":"Nội dung bài viết"}},"widget_17042922":{"content_data":{"content":""}},"widget_17045964":{"content_data":{"content":"Thông tin"}},"widget_17045966":{"content_data":{"content":"Biorich Group<\/strong> provides raw materials and supply chain solutions for the pharmaceutical, nutrition, healthcare, cosmetics, food, and industrial sectors, with a global network of partners.<\/p>\n"}},"widget_17045968":{"content_data":{"content":"Main category"}},"widget_17045974":{"content_data":{"content":"Featured videos"}},"widget_17045984":{"content_data":{"content":"Sign up to receive news"}},"widget_17045991":{"content_data":{"content":"Register"}},"widget_17045988":{"content_data":{"content":"Sign up for our weekly newsletter to get the latest updates.<\/p>\n"}},"widget_17042970":{"content_data":{"content":""}},"widget_17042985":{"content_data":{"content":"Send<\/span>"}},"widget_17042971":{"content_data":{"content":"Send contact information"}},"widget_17042986":{"content_data":{"content":"Reset Form<\/span>"}},"widget_17042989":{"content_data":{"content":""}},"widget_17045961":{"content_data":{"content":"Web designed by P.A Vietnam"}}}