Povidone K17 – Safe and effective viscosity-enhancer

1. General introduction to Povidone K17

Povidone K17 is a non-ionic polymer belonging to the polyvinylpyrrolidone (PVP) family, with a K value of approximately 17 corresponding to a low molecular weight. This provides favorable characteristics such as low viscosity, rapid solubility, and high mobility in solvent systems.

Due to its polar lactam ring structure, Povidone K17 is capable of forming hydrogen bonds with active pharmaceutical ingredients (APIs), thereby enhancing molecular-level dispersion and helping maintain the amorphous state of drug substances. This mechanism plays an important role in improving apparent solubility and reducing recrystallization, particularly for poorly water-soluble compounds.

Povidone K17 is an optimal choice for formulations requiring high safety, good tolerability, and enhanced bioavailability, especially in sensitive dosage forms such as ophthalmic, nasal, and injectable preparations. Beyond pharmaceutical applications, Povidone K17 is also widely used in cosmetics and nutraceutical products due to its high biocompatibility, excellent purity, and ability to improve product sensory properties.

2. Active composition of Povidone K17

Povidone K17 functions as a viscosity-enhancing excipient and solubility-improving agent in pharmaceutical formulations.

Its main component is polyvinylpyrrolidone (PVP), a polymer that is completely soluble in water and many organic solvents, offering high biocompatibility and stability under various formulation conditions.

With its distinctive chemical structure, Povidone K17 serves not only as a viscosity modifier but also as a solubility- and stability-enhancing agent, contributing to the overall performance and effectiveness of the formulation.

3. Key Advantages of Povidone K17

• Low viscosity, ideal for solution systems requiring high clarity and stability
• Rapid solubility, reducing processing time and optimizing manufacturing efficiency
• Enhances the solubility and bioavailability of poorly soluble active ingredients
• Minimizes recrystallization, improving the long-term stability of formulations
• Improves biocompatibility and tolerability, especially in ophthalmic and injectable preparations
• Reduces the risk of accumulation in the body due to its low molecular weight, making it safer for parenteral formulations
• Highly compatible with a wide range of APIs and excipients
• Suitable for various manufacturing technologies such as spray drying and lyophilization (freeze-drying)

4. Applications of Povidone K17

In Pharmaceuticals:

• Viscosity-enhancing excipient for liquid dosage forms
• Binder for tablets and capsules
• Solubility enhancer for poorly soluble active ingredients (BCS Class II and IV)
• Carrier for solid dispersion systems
• Stabilizer for solutions, suspensions, ophthalmic preparations, and injectable formulations
• Film-forming excipient for topical preparations

In Cosmetics:

• Film-forming polymer for gels and hair sprays
• Stabilizer for emulsions and serums
• Provides a smooth, non-greasy skin feel
• Enhances product adhesion and long-lasting performance

In Food & Dietary Supplements:

• Binding excipient for supplement tablets
• Stabilizes beverages and functional foods
• Enhances uniformity and overall product quality

5. Sample Povidone K17 products 

6. Product contact information

For more information about sourcing Povidone K17, please contact us:

• Nutra Hotline: +84 (0) 834 560 500
• Email: biopharma@biorichpharma.com
• Website: www.biorichpharma.com
• Sample / COA Request: Please contact us via email to request samples and the latest Certificate of Analysis (COA).