Polyethylene Oxide (PEO) – Premium Sustained-Release Matrix Excipient from China
1. General Introduction to Polyethylene Oxide
Polyethylene Oxide (PEO) is a synthetic polymer of ethylene oxide with a very high molecular weight (ranging from hundreds of thousands to millions of Daltons). Unlike low molecular weight PEGs, PEO exists as a fine powder, characterized by its rapid hydration, ability to form a dense hydrogel layer, and excellent mucoadhesive properties. It is one of the core excipients in next-generation pharmaceutical formulation technologies.
The material is manufactured by Jiangxi Alpha Hi-Tech Pharmaceutical Co., Ltd, a leading high-tech pharmaceutical enterprise in China specializing in advanced polymer excipients. With a strict GMP-compliant production system, Jiangxi Alpha's PEO provides high purity, tight control over molecular weight ranges, batch-to-batch consistency, and excellent reproducibility for sustained-release formulations.
Material Category: Pharmaceutical Excipients / Matrix-forming excipients, controlled release.
Main Functions: Matrix-forming agent for sustained-release tablets, thickener, film-forming agent, mucoadhesive excipient, and osmotic pump technology agent.
Physical Form: Free-flowing granular powder, white or slightly yellowish, odorless.
Solubility: Highly soluble in water (forming a high-viscosity solution) and soluble in certain polar organic solvents; insoluble in ether and non-polar solvents.
Quality Standards: Meets the standards of the United States Pharmacopeia (USP-NF), European Pharmacopoeia (Ph.Eur), and Chinese Pharmacopoeia (ChP).
The material is strictly controlled for:
Molecular Weight and Viscosity: Precisely controlled across different grades, which directly dictates the drug release rate.
Volatile Organic Impurities: Strict limits on residual solvents and free ethylene oxide content to ensure maximum safety.
3. Advantages of PEO from Jiangxi Alpha
Perfect Controlled Drug Release: Thanks to its hydration capability and stable hydrogel formation, PEO allows active pharmaceutical ingredients (APIs) to be released slowly and steadily through the gastrointestinal tract, reducing the dosing frequency for patients.
Mucoadhesive Properties: Adheres well to the gastrointestinal mucosa, prolonging the gastric retention time and enhancing bioavailability.
Easy Direct Compression: The powder features excellent flowability and compressibility, making it highly suitable for direct compression processes without the need for complex granulation.
Competitive Supply, High Quality: Manufactured in China by Jiangxi Alpha Hi-Tech, it helps pharmaceutical plants optimize production costs (cost-effective) while utilizing materials that meet international pharmacopeia standards.
4. Applications of Polyethylene Oxide
In Pharmaceuticals:
Sustained/Controlled Release Tablets: Used as a hydrophilic matrix-forming excipient for both water-soluble and poorly soluble APIs.
Osmotic Pump Tablets: Serves as the "push layer" that swells upon absorbing water to push the active ingredient out through a laser-drilled orifice.
Mucoadhesive Drugs: Applied in buccal mucoadhesive films or localized suppositories.
In Health Supplements and Cosmetics:
Used as a thickener, smooth film-forming agent, and lubricant in specialized formulations that require high viscosity and biosafety.
5. Commercial Products Using Polyethylene Oxide
6. Product Contact Information
For more information regarding the supply chain, Technical Data Sheets (TDS) for various Polyethylene Oxide molecular weight grades, or to place an order, please contact us:
Sample/COA Request: Please contact us via email to request testing samples and the latest Certificate of Analysis (COA) for the material from the manufacturer Jiangxi Alpha Hi-Tech Pharmaceutical Co., Ltd.
High-quality Polyethylene Oxide raw material from Jiangxi Alpha Hi-Tech Pharmaceutical Co., Ltd (China). An outstanding excipient solution specifically designed for controlled-release tablet formulations and osmotic pump systems. Contact Biorich today!
Polyethylene Glycol ARENTEX PLUS) complies with USP-NF/Ph.Eur standards from manufacturer Aceto Pharma (India). A high-quality liquid excipient and ideal solvent for softgels, liquid dosage forms, and injections. Contact Biorich now!
Premium PEG 6000 (Macrogol 6000) manufactured by Nitika Pharmaceutical Specialities (India). Ideal water-soluble lubricant for effervescent tablets, plasticizer, and suppository base meeting international USP/EP/BP standards. Contact Biorich for samples and COA.
Standard PEG 4000 from Nitika Pharmaceutical Specialities Pvt. Ltd. (India). High-quality pharmaceutical grade ingredient, acting as an effective osmotic laxative and versatile excipient in the formulation of tablets, ointments, and suppositories. Contact Biorich now!
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