Polyethylene Glycol 400 USP-NF/Ph.Eur PARENTEX PLUS – Premium Solubilizer and Excipient from India
1. General Introduction to Polyethylene Glycol 400 (PARENTEX PLUS)
Polyethylene Glycol 400 (PEG 400) is a low molecular weight synthetic polymer that exists in liquid form. With its excellent solubility, good wetting properties, and extremely low toxicity, PEG 400 is one of the most widely used solvents and excipients in the pharmaceutical and health supplement industries, especially in softgel manufacturing technology and liquid dosage forms.
The PARENTEX PLUS brand raw material is manufactured by Aceto Pharma (India) Pvt Ltd, one of the leading reputable excipient suppliers. With a strict quality control system, Aceto Pharma's PEG 400 meets the most rigorous standards of the United States Pharmacopeia (USP-NF) and European Pharmacopoeia (Ph.Eur), ensuring high purity, strict control of hazardous impurities, and absolute stability for formulation recipes.
2. PEG 400 PARENTEX PLUS Material Information
Material Name: Polyethylene glycol 400 (PEG 400 / Macrogol 400) - Brand: PARENTEX PLUS
Manufacturer: Aceto Pharma (India) Pvt Ltd
Origin: India
Material Category: Pharmaceutical Excipients / Solvents, solubility enhancers.
Main Functions: Solvent, co-solvent, liquid base for softgels, excipient for ointments and liquid medicines.
Solubility: Very soluble in water, alcohol (ethanol), acetone, and other glycols; insoluble in ether and fatty oils.
Quality Standards: Meets United States Pharmacopeia (USP-NF) and European Pharmacopoeia (Ph.Eur) standards.
The material is strictly controlled for:
Harmful Impurity Limits: Strict control of Ethylene Glycol and Diethylene Glycol (EG/DEG) content at extremely low levels, ensuring maximum safety for users.
Peroxide and Aldehyde Values: Maintained at a minimum to prevent the degradation of oxidation-sensitive active pharmaceutical ingredients (APIs) in the formulation.
3. Advantages of PEG 400 from Aceto Pharma
Outstanding Bioavailability Enhancement: An excellent solvent that increases the solubility of poorly water-soluble APIs, thereby improving drug bioavailability (especially in softgel formulations containing Ibuprofen, Loratadine, etc.).
High Purity, International Standards: Strict compliance with USP-NF and Ph.Eur standards makes PARENTEX PLUS safe for application in various administration routes, including oral, topical, and even injectable routes.
Chemical Stability: High heat tolerance and stability, compatible with gelatin capsules, helping softgels maintain their shape without leaking or discoloring throughout their shelf life.
Reliable Supply from India: Manufactured by Aceto Pharma, it offers a raw material solution with competitive costs and a stable supply for large-scale pharmaceutical manufacturing plants.
4. Applications of PEG 400 PARENTEX PLUS
In Pharmaceuticals:
Softgels: Used as a fill liquid or solvent to dissolve APIs inside the capsule shell.
Liquid Dosage Forms (Solutions, Oral Syrups): Acts as a co-solvent to dissolve poorly soluble APIs.
Topical Medications: Used as a base excipient for creams and skin ointments, facilitating API penetration and easy removal with water.
Eye Drops and Injectables: Used as a solvent and osmolarity adjusting agent (requires special parenteral grades).
In Health Supplements:
Dietary Supplements: Applied as a liquid carrier for fat-soluble vitamins or poorly soluble herbal extracts.
5. Commercial Products Using PEG 400
6. Product Contact Information
For more information regarding the supply chain, technical specifications of Polyethylene Glycol 400 PARENTEX PLUS, or to place an order, please contact us:
Sample/COA Request: Please contact us via email to request testing samples and the latest Certificate of Analysis (COA) for the material from the manufacturer Aceto Pharma (India) Pvt Ltd.
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