Methacrylic acid & Methylmethacrylate copolymer (1:1) – Enteric film coating excipient, optimizing active ingredient release in the small intestine

1. General Introduction to Methacrylic acid & Methylmethacrylate copolymer (1:1)

Methacrylic acid & Methylmethacrylate copolymer (1:1) is an advanced anionic polymer widely used as an enteric film coating excipient. The biggest difference of this polymer film is its absolute resistance to gastric acid and its ability to begin dissolving and releasing the active ingredient only in the intestinal fluid environment with a pH > 6.0 (usually the jejunum area of the small intestine).

This is an ideal choice for dosage forms that need to protect the active ingredient from degradation by gastric juice, or to prevent the side effect of gastric irritation, while ensuring the maximum concentration of the drug is absorbed at the target location in the digestive tract.

2. Raw Material Information of Methacrylic acid & Methylmethacrylate copolymer (1:1)

• Raw Material Name: Methacrylic acid & Methylmethacrylate copolymer (1:1)
• Origin: India
• Material Group: Pharmaceutical Excipients / Coating agent.
• Function: Enteric coating, controlled release of active ingredients in environments with pH > 6.0.
• Chemical Composition: Copolymer of methacrylic acid and methyl methacrylate at a 1:1 ratio.
• Physical Form: Fine, porous white powder, with a mild characteristic odor.
• Solubility: Insoluble in pure water and gastric acid, highly soluble in dilute alkaline environments (pH > 6.0) and organic solvents such as ethanol, isopropanol, acetone.
• Quality Standards: Complies with current international pharmacopoeias (USP/Ph.Eur/BP).

The raw material is strictly controlled for:

• Copolymer Ratio: Controlled with absolute precision to ensure the coating film dissolves exactly in the target environment (pH > 6.0).
• Impurity Limits: Ensures high chemical stability and excellent compatibility with a variety of sensitive active ingredients.

3. Advantages of the Raw Material

• Optimal Active Ingredient Protection: Completely prevents the degradation of active ingredients easily destroyed by gastric acid (such as peptides, enzymes, antibiotics, probiotics).
• Precise Targeted Release: The coating film dissolves at a pH threshold > 6.0, helping the active ingredient not to be released too early but concentrated in the middle part of the small intestine (jejunum), significantly increasing bioavailability.
• Gastric Mucosa Protection: Creates a safe barrier, helping to avoid side effects that cause ulcers and irritation from certain specific drugs (such as NSAIDs).
• Excellent Film-Forming Ability: The polymer creates a uniform, glossy, tough film with good adhesion on all preparation surfaces such as tablets, capsules, or pellets.

4. Applications of Methacrylic acid & Methylmethacrylate copolymer (1:1)

In Pharmaceuticals (Core Application)

• Film Coating of Tablets and Hard Capsules: Specially used to produce enteric-coated dosage forms, protecting the stomach and ensuring drug absorption in the small intestine.
• Pellet Coating and Multiple Unit Pellet System (MUPS): Widely applied in controlled release systems, helping to disperse doses evenly, minimizing local irritation, and optimizing treatment efficacy.

In Health Supplements

• Protection of Probiotics and Sensitive Nutrients: Used as a protective coating for digestive enzymes and probiotics, helping them pass through the stomach safely and bloom in the small intestine to maximize their effects.

5. Commercial Products Using Methacrylic acid & Methylmethacrylate copolymer (1:1)

6. Product Contact Information

For more information about the supply chain, technical specifications of Methacrylic acid & Methylmethacrylate copolymer (1:1) or to place an order, please contact us:

• Consultation Hotline: +84 (0) 834 560 500
• Email: director@biorichgroup.com
• Website:www.biorichgroup.com
• Request for Sample/COA: Please contact us via email to request a sample and the latest Certificate of Analysis (COA) of the raw material.