Methacrylic acid copolymer – Versatile film coating excipient, effective controlled release and active ingredient protection

1. General Introduction to Methacrylic acid copolymer

Methacrylic acid copolymer is a group of synthetic polymers widely used and indispensable in the modern pharmaceutical industry. Depending on the ratio and combined ester derivatives, this polymer group provides resistance to the acidic environment of the stomach and only dissolves at specific pH levels in the intestinal tract.

This is a versatile film coating excipient solution, not only helping to protect sensitive active ingredients from degradation by gastric juice but also playing an important role in controlled release and sustained release systems, ensuring the drug takes effect at the correct target location.

2. Raw Material Information of Methacrylic acid copolymer

• Raw Material Name: Methacrylic acid copolymer
• Material Group: Pharmaceutical Excipients / Film coating and controlled release excipient.
• Function: Enteric coating, controlling the rate and location of active ingredient release, protecting the gastric mucosa.
• Chemical Composition: Copolymers synthesized from methacrylic acid and its esters (such as methyl methacrylate or ethyl acrylate).
• Physical Form: White to off-white powder, porous granules or aqueous dispersion.
• Solubility: Resistant to water and gastric acid, highly soluble in intestinal fluid environments (depending on the specific type, it can dissolve at pH > 5.5, pH > 6.0, or pH > 7.0) and organic solvents.
• Quality Standards: Complies with current international pharmacopoeias (USP/Ph.Eur/BP).

The raw material is strictly controlled for:

• Molecular Weight and Functional Group Ratio: Ensures precise pH-dependent solubility properties with absolute accuracy.
• Residual Solvents and Impurity Limits: Ensures the highest purity, safety for users, and optimizes the stability of the finished product.

3. Advantages of the Raw Material

• High Versatility: Provides multiple dissolution options at different pH thresholds, suitable for target release in the duodenum, jejunum, or colon.
• Perfect Active Ingredient Protection: Creates a solid barrier, preventing the impact of gastric acid on easily destroyed active ingredients (such as enzymes, antibiotics, probiotics, peptides).
• Effective Controlled Release: Supports the production of sustained-release dosage forms, helping to maintain stable drug concentrations in the blood, reducing dosing frequency, and limiting side effects.
• Superior Film-Forming Properties: Tough film, good adhesion on various core structures, no cracking during storage or transportation.

4. Applications of Methacrylic acid copolymer

In Pharmaceuticals (Core Application)

• Film Coating of Tablets and Capsules: Used as a stomach-protective coating or enteric coating for analgesics, anti-inflammatories, and gastrointestinal drugs.
• Multiple Unit Pellet System (MUPS) and Pellets: Applied to coat microparticles and microcapsules to control the active ingredient release rate (sustained release, pulsatile release).
• Taste Masking: Certain copolymer lines are used to coat active ingredients with a bitter taste and unpleasant odor, making them easier for patients (especially children) to use.

In Health Supplements

• Protection of Beneficial Bacteria and Nutrients: Protects probiotics, sensitive vitamins, and digestive enzymes from the acidic environment, ensuring they safely reach the intestine to take effect.

5. Commercial Products Using Methacrylic acid copolymer

6. Product Contact Information

For more information about the supply chain, technical specifications of Methacrylic acid copolymer or to place an order, please contact us:

• Consultation Hotline: +84 (0) 834 560 500
• Email: director@biorichgroup.com
• Website:www.biorichgroup.com
• Request for Sample/COA: Please contact us via email to request a sample and the latest Certificate of Analysis (COA) of the raw material.