Dibasic Calcium Phosphate Anhydrous – Premium Diluent for Tablets and Capsules

1. General introduction to Dibasic calcium phosphate anhydrous

Dibasic Calcium Phosphate Anhydrous is a widely used diluent in direct compression, as well as wet and dry granulation processes in generic drug R&D. Compared to microcrystalline cellulose and lactose, Dibasic Calcium Phosphate (DCP) is less hygroscopic and more stable at room temperature. DCP exhibits lower compressibility than microcrystalline cellulose but outperforms lactose. Two grades of Dibasic Calcium Phosphate Anhydrous are commonly utilized in pharmaceuticals:

• Milled: Used in wet and dry granulation, typically featuring an alkaline surface pH.
• Unmilled (Coarse/Granular): Used in direct compression, typically featuring anacidic surface pH.

Dibasic Calcium Phosphate Anhydrous is considered a strategic excipient solution for pharmaceutical companies facing formulation challenges with active pharmaceutical ingredients (APIs) sensitive to moisture, oxidation, and micro-environmental pH.

2. Information on Dibasic Calcium Phosphate Anhydrous

• Material Name: Anhydrous Dibasic Calcium Phosphate
• Material Category: Pharmaceutical Excipient / Micronutrient API
• Chemical Formula: CaHPO₄
• Molecular Weight: 136.06 g/mol
• Appearance: White, odorless, and tasteless powder or granules
• Solubility: Practically insoluble in water, ethanol, and ether. Soluble in dilute acid solutions.
• Hygroscopicity: Non-hygroscopic and does not convert to hydrated forms at room temperature.
• pH: Dibasic Calcium Phosphate hardly dissociates in water, resulting in a near-neutral pH. However, depending on the manufacturing process, the excipient surface may exhibit slightly acidic or slightly alkaline characteristics.
• Quality Standards: Complies with current pharmacopoeial standards (USP / Ph. Eur. / BP / JP).

Usage Considerations for Moisture-Sensitive and Micro-Environmental pH-Sensitive APIs:

• APIs stable in slightly acidic conditions: Select the direct compression method with the unmilled grade.
• APIs stable in slightly alkaline conditions: Select dry granulation with the milled grade, or direct compression with the unmilled grade (Dibasic calcium phosphate dihydrate).
• Grade switching: Consider the API's chemical stability at the corresponding pH when switching grades within a formulation.
• Lubricant ratio: Requires a higher lubricant proportion than MCC, typically starting at about 1.0%.

3. Advantages of Dibasic calcium phosphate anhydrous

• Superior Compressibility: Its primary deformation mechanism is brittle fracture, which generates new bonding surfaces during compaction, ensuring high mechanical strength for tablets.
• High Chemical Inertness: The anhydrous form contains no water of crystallization and is chemically inert, ensuring maximum compatibility with sensitive active pharmaceutical ingredients (APIs).
• Optimal for Bilayer Tablets: Due to its brittle fracture characteristics, it creates strong mechanical inter-layer bonding in bilayer tablet formulations.
• High Bulk Density: High density helps optimize volumetric density uniformity, reducing overall tablet size and making tablets easier for patients to swallow.

4. Applications of Dibasic calcium phosphate anhydrous

In Pharmaceuticals and Dietary Supplements

• Tablets / Capsules: Serves as a diluent that facilitates binding/shaping, increases hardness, and ensures weight/content uniformity.
• Vitamins & Minerals: Provides a stable, highly bioavailable calcium source.

In Food Products

• Fortified Milk Products: Enhances nutritional value and product stability.
• Nutritional Cereals: Improves mineral content and product texture/structure.
• Bakery Products: Functions as a leavening agent and texturizing/stabilizing agent.

In Animal Feed & Agriculture

• Livestock & Poultry Feed Additives: Provides a source of highly bioavailable calcium and phosphorus.
• Mineral Fertilizers: Delivers slow-release phosphate nutrients for crops, supporting root system development.

5. Commercial products using Dibasic calcium phosphate anhydrous

6. Product contact information

For more information about Dibasic calcium phosphate anhydrous supply, please contact us:

• Hotline: +84 (0) 834 560 500
• Email:director@biorichgroup.com
• Website: www.biorichgroup.com
• Sample / COA request: Please contact via email to receive the latest samples and Certificate of Analysis (COA).