Cetyl alcohol – premium structuring excipient

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1. General introduction to Cetyl Alcohol

Cetyl Alcohol is a fatty alcohol widely used in pharmaceutical and cosmetic formulations, including suppositories, modified-release solid dosage forms, emulsions, lotions, creams, and ointments. In pharmaceutical applications, it serves multiple functional roles and is commonly used for the following purposes:

Modified-release solid dosage forms: Cetyl Alcohol may be used to form a permeable barrier coating
Suppositories: Cetyl Alcohol is used to raise the melting point of the base
Emulsions, lotions, creams, and ointments: Cetyl Alcohol functions as an emollient, water-absorbing agent, and emulsifier in both oil-in-water (O/W) and water-in-oil (W/O) emulsions. When used in combination with hydrophilic emulsifying agents, it significantly enhances emulsification efficiency and improves the stability of emulsions, including semisolid emulsion formulations.

2. Chemical composition of Cetyl Alcohol

Material Name : Cetyl Alcohol (Cetanol)
Empirical formula : C₁₆H₃₃OH
Appearance : occurs as white or cream-colored unctuous masses, flakes, pellets or granules, with a characteristic odor
Soubility : freelysoluble in ethanol (95%), ether, and oil; practically insoluble in water
Melting range : 49°C (depending on the purity of the excipient)
Incompatibilities : Cetostearyl alcohol is incompatible with strong oxidizing agents. In addition, Cetyl Alcohol has been reported to lower the melting point of ibuprofen. Therefore, caution should be exercised when using it in film coating formulations for tablets containing ibuprofen cores.

The material is rigorously controlled for the following parameters:

Identification and assay of cetyl alcohol
Melting range (46°C - 53°C)
Acid value, iodine value, hydroxyl value and saponification value

3. Key advantages of Cetyl Alcohol

Multilayer Protection Against Emulsion Breakdown: In oil-in-water (O/W) emulsions, Cetyl Alcohol interacts with hydrophilic emulsifying agents to form a close-packed, monomolecular interfacial film at the oil–water interface. This protective mechanical barrier effectively inhibits droplet coalescence, thereby improving the physical stability of the emulsion.
Superior Water-Binding Capacity: In water-in-oil (W/O) emulsions, Cetyl Alcohol functions as a water absorption property, emulsifier, and increases the consistency of water-in-oil emulsions. These combined functions increase the oil phase's capacity to incorporate the aqueous phase, facilitate emulsification, and improve the overall stability of the emulsion system.
Broad Formulation Compatibility: Cetyl Alcohol is highly compatible with a wide range of active pharmaceutical ingredients (APIs), oils, waxes, emulsifying agents, and other pharmaceutical excipients. This broad compatibility provides greater flexibility in formulation development and supports the design of diverse topical dosage forms while maintaining formulation stability.

4. Applications of Cetyl Alcohol

In pharmaceuticals

Coating agent in modified-release solid dosage forms and moisture-protective film-coated tablets
Suppositories, Cetyl Alcohol is used to raise the melting point of the base, improving the physical stability of the dosage form and facilitating manufacturing and transportation.
Topical Formulations, Cetyl Alcohol functions as an emollient, helping to improve skin penetration and reduce the irritation potential of active pharmaceutical ingredients (APIs)
Cetyl Alcohol acts as an effective co-emulsifier, enhancing the performance of primary emulsifying agents, reducing the amount of emulsifier required, and improving the stability of products, including emulsions, lotions, creams, and ointments

In premium cosmetics

Skincare creams: create a smooth texture, improve softness, and enhance moisturization
Lotions: Stabilize emulsions and improve sensory feel
Hair care products: Provide conditioning effects, leaving hair smooth and manageable

5. Commercial products using Cetyl Alcohol

6. Product contact information

For more information about Cetyl Alcohol supply, please contact us:

Hotline: +84 (0) 834 560 500
Email: director@biorichgroup.com
Website: www.biorichgroup.com
Sample / COA request: Please contact us via email to receive product samples and the latest Certificate of Analysis (COA).

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Cetyl alcohol – Advanced structuring and controlled release excipient

1. General introduction to Cetyl Alcohol

2. Chemical composition of Cetyl Alcohol

3. Key advantages of Cetyl Alcohol

4. Applications of Cetyl Alcohol

In pharmaceuticals

In premium cosmetics

5. Commercial products using Cetyl Alcohol

6. Product contact information

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