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Calcium carbonate – An inorganic salt that supports bone strength and digestive balance, and serves as a diluent for solid dosage forms

Calcium Carbonate is an inorganic calcium salt that supports bone strength and helps neutralize gastric acid in pharmaceutical and dietary supplement formulations. In addition, Calcium Carbonate is widely used as a diluent and buffering agent in solid dosage forms.

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    1. General introduction to Calcium Carbonate

    Calcium Carbonate (CaCO₃) is an inorganic calcium salt composed of calcium ions (Ca²⁺) and carbonate ions (CO₃²⁻), commonly found in nature as limestone, marble, and chalk. It is one of the highest natural sources of calcium and is widely used across industries today.

    Calcium Carbonate is widely used in pharmaceuticals and dietary supplements due to its high calcium content and natural alkalinity, helping support bone mineralization and neutralize excess gastric acid. These dual mechanisms make it a strategic ingredient in products targeting bone health and digestive wellness.

    In pharmaceutical formulations, Calcium Carbonate is also commonly used as a diluent, binder, a buffering agent, and an opacifying agent in film-coating systems.

    2. Active composition of Calcium Carbonate

    Main component: Calcium Carbonate (CaCO₃)

    Functional roles:

    • Provides a high elemental calcium content (~40%)
    • Neutralizes stomach acid (antacid effect)
    • Supports mineral balance in the body
    • Diluent in solid dosage form
    • Buffering agent
    • Opacifier for film coated 

    3. Key Advantages of Calcium Carbonate

    • An effective alternative to titanium dioxide (TiO₂), featuring exceptional natural whiteness, a uniform crystal structure, and an optimized refractive index. These properties enable calcium carbonate to provide excellent opacity and hiding power in film coating applications.
    • High elemental calcium content (~40%) enables efficient calcium supplementation with lower doses, optimizing cost and formulation space
    • pH buffering capacity allows rapid neutralization of stomach acid, ideal for digestive support products
    • High chemical stability extends shelf life and minimizes interactions with other ingredients
    • Good compressibility and flowability compatible with various formulation processes.
    • Dual functionality (calcium supplementation + antacid) reduces the number of raw materials in formulations

    4. Applications of Calcium Carbonate

    API in Pharmaceuticals and Nutraceuticals:

    • Bone health products: Widely used as the primary calcium source to maintain bone density and structural strength. Its high elemental calcium content makes it suitable for long-term supplementation.
    • Digestive and antacid products: Acts as a key ingredient in digestive aids and antacid formulations. It reacts with stomach HCl to reduce acidity, alleviating symptoms such as heartburn, acid reflux, and stomach discomfort.
    • Multi-functional products: Often used as a dual-purpose ingredient to provide calcium supplementation and acid neutralization, optimizing formulation efficiency and market value.

    Excipient:

    • Diluent in solid dosage form such as tablet, hard capsule, sachet and granule
    • Supports binder excipient functionality
    • Buffering agent, dissolution aid in dispersible tablets
    • An opacifying agent for pharmaceutical film coatings, serving as an excellent alternative to titanium dioxide (TiO₂). 
    • Bulking agent in tablet sugar-coating process

    5. Commercial products using Calcium Carbonate

     

    6. Product contact information

    For more information on sourcing Calcium Carbonate, please contact us:

    • Hotline: +84 (0) 834 560 500
    • Email: director@biorichgroup.com
    • Website:www.biorichgroup.com
    • Sample/COA Request: Please contact us via email to request a sample and the latest Certificate of Analysis (COA) for the raw material from the manufacturer Nitika Pharmaceutical Specialities Pvt. Ltd.
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