Ammonium Glycyrrhizate – Anti-Inflammatory And Skin-Soothing Active Ingredient In Pharmaceutical And Cosmetic Applications

1. General introduction to Ammonium Glycyrrhizate

Ammonium Glycyrrhizate is a bioactive compound extracted from the root of licorice plant (Glycyrrhiza glabra L.). Chemically, it is the ammonium salt of glycyrrhizic acid - a natural saponin compound well known for its powerful anti-inflammatory and skin-soothing properties.

In the pharmaceutical and cosmetic industries, Ammonium Glycyrrhizate is considered a high-value functional ingredient. It is widely incorporated into formulations designed to reduce skin irritation, calm inflamed skin and improve the condition of sensitive skin.

Thanks to its natural origin and excellent safety profile, this ingredient is commonly used in premium skincare products, dermatological treatments and lip care formulations.

2. Active components of Ammonium Glycyrrhizate

Typical technical specifications:

• Chemical name: Ammonium Glycyrrhizate
• Molecular formula: C42H65NO16
• Appearance:White or yellowish-white
• Solubility:Slightly soluble in water
• Source:Extracted from natural licorice root (Glycyrrhiza glabra L.)

This active compound demonstrates strong biological activity, particularly in anti-inflammatory, antioxidant and skin-conditioning functions, making it a valuable ingredient for pharmaceutical and cosmetic formulations.

3. Key advantages of Ammonium Glycyrrhizate

Ammonium Glycyrrhizate offers multiple advantages in both pharmacological activity and formulation compatibility, making it one of the key functional ingredients in modern pharmaceutical and cosmetic manufacturing.

• Powerful anti-inflammatory mechanism:Ammonium Glycyrrhizate can inhibit inflammatory mediators such as prostaglandins and cytokines, helping to reduce symptoms of inflammation including redness, swelling, and irritation. This mechanism makes it highly effective in dermatological formulations and products designed for sensitive skin.
• Skin-soothing and anti-irritation properties:The ingredient helps stabilize the skin barrier and reduce sensations of burning, itching, and discomfort caused by environmental stressors or cosmetic ingredients. For this reason, Ammonium Glycyrrhizate is frequently used in formulations for sensitive or damaged skin.
• Antioxidant protection: The glycyrrhizic acid component of Ammonium Glycyrrhizate has antioxidant properties that help neutralize free radicals. This protective effect helps prevent oxidative stress caused by UV exposure, pollution, and other environmental factors that can damage skin cells.
• High formulation compatibility:Ammonium Glycyrrhizate is relatively stable, allowing it be easily incorporated into various formulation systems, including: cream, lotions, gels, serums, aqueous skincare solutions. This flexibility allows manufacturers to apply the ingredient across a wide range of cosmetic and pharmaceutical products.
• Natural origin and high safety profile: Derived from licorice root extract, Ammonium Glycyrrhizate is a naturally sourced ingredient with a long history of safe use in pharmaceutical and cosmetic applications. Its safety profile makes it particularly suitable for products intended for sensitive skin.

4. Applications of Ammonium Glycyrrhizinate 

Due to its diverse biological activities, Ammonium Glycyrrhizate is widely used in both pharmaceutical and cosmetic products:

• Dermatological anti-inflammatory treatments: In dermatological pharmaceuticals, Ammonium Glycyrrhizate is commonly used in products designed to support the treatment of conditions such as dermatitis, eczema, and allergic skin reactions. The ingredient helps reduce redness, inflammation, and skin irritation.
• Skincare products for sensitive skin: Ammonium Glycyrrhizate is frequently included in skincare formulations designed for sensitive or reactive skin. It improves skin tolerance and helps reduce irritation caused by environmental or cosmetic factors.
• Lip care and lipstick formulations: In lip care products such as lip balms, lipsticks and lip glosses. 
• Acne care products:Due to its anti-inflammatory properties, Ammonium Glycyrrhizate is often used in: anti-acne serums, calming facial toners and redness-reducing skincare products
• Cleansing and skin recovery products:This ingredient is also commonly found in facial cleansers, soothing masks, and post-treatment skin recovery products, helping maintain balanced, healthy skin.

5. Commercial products using Ammonium Glycyrrhizate 

6. Product contact information

For more information about Ammonium Glycyrrhizate supply, please contact us:

• Hotline: +84 (0) 834 560 500
• Email:director@biorichgroup.com
• Website: www.biorichgroup.com
• Sample / COA request: Please contact via email to receive the latest samples and Certificate of Analysis (COA).