Povidone K90 - Sustained-release matrix-forming excipient

1. General introduction to Povidone K90

Povidone K90 is a synthetic polymer belonging to the polyvinylpyrrolidone (PVP) family, characterized by a K value of approximately 90, representing its high molecular weight and significantly higher viscosity compared to other PVP grades. These properties make Povidone K90 particularly suitable for sustained-release tablet formulations.

Due to its complete water solubility and ability to form highly viscous solutions, Povidone K90 can readily establish a robust polymer network that functions as a matrix system, helping to retain active ingredients and thereby prolong drug release.

2. Mechanism of Drug Release 

Povidone K90 forms a hydrophilic matrix system. Upon contact with gastrointestinal fluids, the matrix swells, and the tablet surface becomes hydrated, forming a viscous gel layer. This gel layer acts as a barrier controlling drug release, requiring the active ingredient to diffuse through the gel before being released into the surrounding environment.

3. Key advantages of Povidone K90 

Povidone K90 offers several advantages in sustained-release tablet formulation:

• Provides flexibility in formulation design for controlling drug release rates
• High viscosity helps stabilize the tablet matrix and minimize dose dumping
• Enhances tablet hardness and mechanical strength while maintaining effective drug release performance
• Promotes uniform distribution of the active ingredient within the matrix system
• Compatible with various manufacturing processes
• Suitable for formulations containing high drug loads, poorly compressible ingredients, or APIs that are difficult to control in release profiles

4. Applications of Povidone K90 

Povidone K90 is used in the following pharmaceutical applications:

• Matrix-forming excipient for sustained-release formulations
• Binder for tablets, helping improve tablet hardness in formulations containing high drug loads or poorly compressible ingredients
• Viscosity-enhancing, suspending, and stabilizing agent for liquid formulations

5. Sample Povidone K90 products

6. Product contact information 

For more information regarding Povidone K90 sourcing, please contact us:

• Hotline: +84 (0) 834 560 500
• Email: biopharma@biorichpharma.com
• Website: www.biorichpharma.com
• Sample / COA request: Please contact us via email to receive samples and the latest Certificate of Analysis (COA).